Thursday, August 14, 2014

Winstrol – Injectable Vs Oral


Winstrol can be used as either an oral or an injectable steroid. It is important to find out about both methods because you will get different results depending on the way you decide to administer it. The steroid Winstrol comes from the base structure of DHT. This is simply testosterone with 5alpha reduced. The c4-5 double bond has been removed using two hydrogen atoms. DHT does not aromatize into estrogen. While both forms of Winstol are the same the oral type offers a micronized Stanozolol powder that is suspended in water.

Winstrol offers a couple of modifications – c17methylation so that it can get past the liver on the first pass. A pyrazol group is added as well giving it a 5 sided group of Cyclopentane. The anabolic rate of Winstrol is very high with 320% testosterone. This results in the individual gaining strength and losing fat as long as they maintain a strict diet.

Winstrol comes from DHT and it is known to have antestrogenic effects. It also features anti-progestenic properties that block the receptors. The hard look your physical appearance takes on from Winstrol is the result of the estrogen and progesterone. The body looks very smooth as a result. It is important for you to know that it is 17aa meaning it is toxic to the liver. It is even more toxic to the liver when the method used is injection. This is because when a drug is consumed orally it takes a first pass into the liver so that only a portion of it actually gets into the blood stream.

In most cases, the first pass of Winstrol will take place in the gut and the liver. After it has been metabolized it will enter the bloodstream. Any blood that is metabolized in the gastrointestinal tract won’t go directly to the heart. Instead it passes from the liver to the hepatic vein through the portal vein. The liver is the system in your body responsible for filtering excess nutrients, toxins, and various substances that shouldn’t be in your bloodstream.

Oral steroids including Winstrol must first make a pass through the metabolism in the intestines and then again in the liver. Some of the various oral steroids are able to be absorbed intact while others are absorbed after metabolic activity has taken place. During the first pass is completed the drug is allowed to move through the body until another tissue absorbs it.

You will find some huge differences between the body’s reaction to the injectable and the oral methods of consuming Winstrol. The injectable option allows it to be placed directly into the bloodstream so it only has to go through the second pass metabolism while the oral version has to go through the gut and the liver before it is circulated into the bloodstream.

If you choose to inject Winstrol you will get more nitrogen retention than taking the oral version. This allows more muscle tissue to grow. If that is your goal then of course you will want to use the injectable method. They oral method does offer some good advantages though. Taking this first pass though allows the drug to be exposed to various enzymes and proteins.

To help you understand they synergy between Winstrol and the other steroids out there let me offer you some information on Sex Hormone Binding Globulin (SHBG). This is a Glycoprotein that is produced in the liver. More than half of the testosterone in your body is actually SHBG, and you can lower the amount of it when you consume Winstrol. A dose as low as .2mg per kg of body weight will help you reduce the amount of SHBG by 50%.

You may be wondering why you can’t get the same results with the oral method. This is because of the first pass it has to take through the liver. The Winstrol interacts with SHBG that is produced in the liver. It doesn’t go through the bloodstream first. Studies have shown that the injectable method of Winstrol is more effective than the oral when 700 mgs are injected per week vs. 400 mgs per week consumed orally.

For women, the opposite is true – they need to use the injectable method of Winstrol. The oral version offers need more synergy in their cycles but women want to avoid this. When women have less SHBG they have more testosterone and that can lead to hirsuitism which is an abnormal growth of body hair. It can also affect their menstrual cycle. Some women find their clitoris becomes enlarged and they suffer from severe acne when they use the oral method of Winstrol.

It is common for males who use the oral method of Winstrol to have more acne as well. Both men and women need to watch for liver toxicity issues as well. This steroid has one of the highest occurrences of that. The best advice I can give you is to use Winstrol if you like, but don’t use too much of it and don’t use it too often.

Friday, August 8, 2014

Alcohol's Effects on Testosterone


The majority of research conducted in the past 25 years, in both animals and humans, has found that alcohol inhibits testosterone secretion. However, a new study found that alcohol can induce a rapid increase in plasma and brain concentrations of testosterone in some rodents. "We have demonstrated that there are very different results in the way two different groups of male rats form testosterone after acute administration of alcohol," said Robert H. Purdy, senior staff scientist in the department of neuropharmacology at The Scripps Research Institute and senior author of the study. "These differences in animals may reflect similar individual differences in humans, and provide new insights for understanding individual differences in the behavioral and endocrine pathology associated with alcohol abuse."

According to the ACER report: Researchers "injected either alcohol or 1,1-dideuteroethanol (2 g alcohol/kg body weight) into the abdominal cavities of two groups of rats, 30 un-operated and 24 adrenalectomized and castrated (ADX/GDX) Wistar males. 1,1-dideuteroethanol is a nonradioactive form of alcohol in which two of the hydrogen atoms on carbon atom #1 of ethanol have been replaced by deuterium atoms, which can then be traced."

They then used mass spectrometry to determine both the amount of neuroactive steroids present and the degree of deuterium in specific neuroactive steroids isolated from brain samples.

The resarchers found that concentrations of testosterone increased fourfold in the frontal cortex and threefold in the plasma of the un-operated rats 30 minutes after alcohol administration. ADX/GDX rats had testosterone concentrations that were only five percent of those found in the un-operated rats after alcohol injection. The findings demonstrated that alcohol oxidation is directly linked to testosterone biosynthesis, the authors said.

"Our finding of a direct link between alcohol administration and the level of the neuroactive steroid testosterone in the brain of these experimental animals was unanticipated from prior studies with another species of rats," Purdy said.

"Although many other studies clearly demonstrate that chronic consumption of high dosages of alcohol appears to be consistently inhibitory and suppresses reproductive function," said Dennis D. Rasmussen, research associate professor in the department of psychiatry at the University of Washington, "this study raises the possibility that episodes of alcohol consumption may also at least temporarily increase testosterone levels, with the direction of the response likely being dependent upon a variety of factors, including dosage and personal characteristics.

"This particular dosage produced blood alcohol levels and behavioral responses consistent with intoxication. So, alcohol consumption, under at least some conditions and by at least some individuals, may acutely stimulate testosterone levels in the plasma and brain of both males and females and thus could elicit some of the behavioral effects associated with increased testosterone levels, such as increased libido or aggression."

Rasmussen said, his findings join those of two other studies in which alcohol administration increased plasma testosterone levels in a gender- and dose-dependent manner. "Together these studies are important," he said, "because they illustrate that what has become a largely accepted principal - that alcohol consumption inhibits plasma testosterone levels and reproductive function - is not universally true."

Rasmussen suggested that future research build upon and add to previous findings regarding alcohol's effects on testosterone. "It would be important to determine whether lower dosages of alcohol, which do not induce rapid pronounced intoxication and ataxia, would also produce the acute increase in testosterone, and whether this response to lower dosages would be consistent across different strains of rats. Also, does tolerance develop with repeated administrations?

"Does this increase in testosterone occur following elective self-administration of alcohol? Finally, and probably most interesting, what role might the demonstrated changes in testosterone play in behavioral responses to acute ethanol consumption? Are there gender differences in these responses? And, if the responses do occur in females, are they different during different stages of a woman's cycle?"