These days, there probably isn’t a bodybuilder alive that hasn’t heard of Trenbolone. In today’s drug circles, it has attained nearly super-hero status as an anabolic agent. “Nectar of the gods”…“A steroid on steroids”…and “indispensable” are just some of the terms which have been used to describe this highly desirable drug. There is no single characteristic responsible for Trenbolone’s unique effects on the musculature. Rather, it is a precise combination of attributes which provide such amazing results.
There are few non-methylated drugs capable of functioning as both a mass builder and cutter, while excelling at both. In fact, if pressed to name another non-methylated drug capable of duplicating trenbolone’s performance. Typically, Trenbolone is known for its ability to generate substantial gains in dense, dry muscle tissue; a trait which has no doubt earned it a top spot in both contest prep and off-season programs alike. Likewise, its strength building and psyche altering capabilities have made it popular among strength-power athletes, but rather than re-hash these well known traits, I want to spend a bit of time talking about some of the less publicized qualities of Trenbolone.
One often debated topic in the steroid world is the role of estrogen in the muscle growth process. Up until the last decade, many bodybulders were taught to avoid the use of anti-estrogenic drugs when in the off-season, as it was commonly believed that the elevated estrogen level achieved with aromatizable drugs was necessary for maximizing muscle growth. This belief was born out of real-world experience, with many bodybulders noting a reduction in overall weight gain when administering these drugs. Were these old-school bodybulders simply confusing estrogen induced water retention with genuine muscle growth, or was there more to the story? In recent years, the phobia surrounding anti-estrogenic drugs has greatly diminished. While science has confirmed the importance of estrogen in the growth process, most steroid users now believe that keeping levels within the low-normal range is more than sufficient to obtain all its growth benefits. To this end, aromatase inhibitors such as Aromasin and Arimidex are freely employed in the programs of today’s steroid using bodybulders. So, how does this apply to trenbolone, a non-aromatizing steroid, you might ask?
In recent years, the phobia surrounding anti-estrogenic drugs has greatly diminished. While science has confirmed the importance of estrogen in the growth process, most steroid users now believe that keeping levels within the low-normal range is more than sufficient to obtain all its growth benefits. To this end, aromatase inhibitors such as Aromasin and Arimidex are freely employed in the programs of today’s steroid using bodybuilders. So, how does this apply to trenbolone, a non-aromatizing steroid, you might ask?
Trenbolone may also stimulate growth through enhanced proliferation and differentiation of satellite cells, which may be mediated through an increase in IGF-1 sensitivity. In order to understand why this is important, let’s first look at the role of satellite cells in the muscle growth process. After a hard training session, the muscle cell proteins within muscle fibers sustain damage, which activates a special type of stem cell known as satellite cells. These cells, which are located between the basal lamina and plasma membrane (an area directly outside the muscle fibers), are quickly shuttled to the site of injury, initiating the muscle regeneration process. They then begin to multiple (proliferate) by fusing to other satellite cells and to existing muscle fibers. A portion of these satellite cells will remain as organelles, but the majority will differentiate (the process of turning immature stem cells into mature muscle cells) and fuse to muscle fibers, either creating new muscle protein stands (myofibrils) or helping to repair previously damaged muscle fiber. The formation of these myofibrils (muscle fibers) directly leads to an overall increase in the size of the muscle.
This muscle repair process is aided by numerous growth factors, such as testosterone, growth hormone, insulin, IGF-1, HGF, and FGF. These hormones influence the rate and amount of protein that is deposited in the muscle during the repair process, with higher levels speeding up the muscle growth process and lower levels slowing down the process. In particular, IGF-1 and FGF have a direct influence on the proliferative response of satellite cells. In multiple studies, trenbolone has been shown to enhance this proliferative response, which the researchers suggest is due to trenbolone’s ability to increase satellite cell sensitivity to IGF-1.