Friday, September 12, 2014

Winter Bulk Cycle with Oral Anabolic Steroid for Added Mass Gains.

Bulking is an art. An art that takes a ton of effort to be successful at. Especially when you are a seasoned juicer who has already put on some mass. If you have not gained at least 20 pounds over the weight you were at before coming over to the dark side, you just have not been juicing effectively and you will be very happy with the information that follows. If you have put on a good deal of size, you will still find useful information in the following paragraphs, but for now, we will not discuss usage of other non-anbolic steroid bulking drugs such as insulin. We will get to that soon though. Keep reading!

The catch with bulking drugs is that you have to accept not being so pretty if you are to really put on some size. Water and a little fat weight have to come with adding considerable size unless you are a genetic abnormality. The most potent drugs for bulking involve the heavy androgenic drugs which also cause large amounts of water retention. All the testosterone esters, anadrol, dianabol, and deca or equipoise when combined with any of the former make for a good bulking team.

One thing you want to take into consideration with here is the mechanism by which each drugs works. Anabolic steroids are either known to have a high affinity for the androgen receptor, and thereby cause growth through this mechanism, or they have effects on growth outside the receptor. For max benefit you want to combine drugs that work by different mechanisms. All orals will work by different mechanism purely on the fact that they are ingested and not injected. The way you get a drug into your body is called the route of administration. When an oral drug is taken it must eventually pass its way through the liver. The first time it does this a few hours after you ingest the oral is the popular term, "first pass". This is just code for the first time the liver has a chance to break down the oral drug. This site of metabolism is also where the functionality of oral anabolic steroids come into play.

The 17 alkylation of oral anabolics is what makes the drug able to pass the liver and not be fully degraded. Otherwise you would be able to drink testosterone and it would work fine. We all know this is not the case. The hydrochloric acid in the stomach would destroy the testosterone molecule way before the liver even gets a chance to metabilize it. This is why the oral test "methyltestosterone" came into existence. Although it is not a very effective drug, it is highly toxic. Methyltestosterone is a prototype oral. It has the most basic of structures added to testosterone to enable its hepatic(liver) survival. They simply added a CH3 or "methyl" group to the 17th postiion on th molecule (you've most likely seen it, it is the thatched roof part of the steroid structure). The reason why I mention this is that the toxicity of orals due to their chemical make-up is not all bad. When a 17 orally alkylated drug passes by the liver, it forces the liver to kick out a little extra IGF-I each time. IGF-I is the most potent anabolic substance in the body. It is through IGF-I modulation that the use of growth hormone exerts its muscle building effects.

The moral of the story:
Regular old testosterone is one of the best bulking drugs there is. As long as you are not super sensitive to estrogenic side effects, this should be your staple for mass building. Novices usually use around 500mg a week of a long acting ester. More advanced bodybuilders use upwards of 1000mg a week. The best way to do this is to find yourself some cheap multi-dose vials of a long acting test like enanthate. But I'm not "telling you to do this", ummm...this is for information purposes only...ok...hypothetically...If you use a shorter acting ester like propionate, it will be much more painful to administer and you will definitley not administer this amount. Prop at 100mg eod is more the norm for novices, 100-200mg daily for advanced. Prop usually comes 100mg/cc, two cc's in one shot of prop hurts!! You will definitely experience some welting if you try this. I do not recommend it. You will either be limping or rubbing your shoulder almost daily. This is miserable. Long acting esters like sustanon, enanthate, cypionate, etc. do not cause this extrem discomfort. Please keep this in mind.

Okay, so we have an oral, either Dianabol or Anadrol, with an injectible testosterone, and now you need a even blood level anabolic like deca or equipoise. Either one will suffice. Remember though, as we've said before, combining aromatizing drugs such as anadrol testosterone esters with progestagenic drugs such as anadrol is very risky for all but those who are not susceptible to gyno. So be careful. Even if you have used androgenic drugs such as test before with no chest soreness, be careful. If you decide to do this, you will want at least one estrogen on hand for precautionary reasons.

Assuming all is well, and you choose to take this aggressive technique, you will need at least a 2mg/lb of bodyweight per week of the injectible anabolic. You could technically use primo or winstrol as well for a little less overall bloat. The dosage patterns will be different with these drugs if used for this purpose and we will talk about this in the future. For now lets assume either Deca Durabolin or Equipose. Deca Durabolin at 300-400mg/week is often used by novices, 600-800mg for advanced. In all the athletes I have known, I have not seen a reason to go above 500mg when combining Deca Durabolin or Equipose with both an oral and a testosterone ester. This dose should be more than enough to get you gaining and keep your joints from aching while you push all that heavy iron (we will get into joint/ligament/tendon properties of anabolics soon).

Friday, September 5, 2014

Clomid by Dragon Pharma

Clomid 50mg by Dragon Pharma is an oral preparation containing 50mg of the substance Clomiphene Citrate.

Clomid, as it is most often called, is one of the most popular PCT drugs today, and is a staple of most bodybuilder's protocol. Clomid is typically prescribed for women to aid in ovulation. In men, the application of Clomid causes an elevation of follicle stimulating hormone and luteinizing hormone. As a result, natural testosterone production is also increased. This effect is obviously beneficial to the athlete, especially at the conclusion of a cycle when endogenous testosterone levels are subnormal. Clomid will gradually raise testosterone levels over its period of intake.

Clomid is typically prescribed for women to aid in ovulation. In men, the application of Clomid causes an elevation of follicle stimulating hormone and luteinizing hormone. As a result, natural testosterone production is also increased. This effect is obviously beneficial to the athlete, especially at the conclusion of a cycle when endogenous testosterone levels are subnormal. Clomid will gradually raise testosterone levels over its period of intake.

Clomid is also effective as an anti-estrogen. With the intake of Clomid, the athlete gets the dual effect of blocking out some of the effects of estrogen, while also increasing endogenous testosterone production.

Users often take the drug in a dosage of 100-150mgs a day for 4-6 weeks following the end of a cycle. Users often add substances such as HCG and proviron to make their PCT plan even more sound and effective.

Thursday, August 14, 2014

Winstrol – Injectable Vs Oral

Winstol can be used as either an oral or an injectable steroid. It is important to find out about both methods because you will get different results depending on the way you decide to administer it. The steroid Winstrol comes from the base structure of DHT. This is simply testosterone with 5alpha reduced. The c4-5 double bond has been removed using two hydrogen atoms. DHT does not aromatize into estrogen. While both forms of Winstol are the same the oral type offers a micronized Stanozolol powder that is suspended in water.

Winstrol offers a couple of modifications – c17methylation so that it can get past the liver on the first pass. A pyrazol group is added as well giving it a 5 sided group of Cyclopentane. The anabolic rate of Winstrol is very high with 320% testosterone. This results in the individual gaining strength and losing fat as long as they maintain a strict diet.

Winstrol comes from DHT and it is known to have antestrogenic effects. It also features anti-progestenic properties that block the receptors. The hard look your physical appearance takes on from Winstrol is the result of the estrogen and progesterone. The body looks very smooth as a result. It is important for you to know that it is 17aa meaning it is toxic to the liver. It is even more toxic to the liver when the method used is injection. This is because when a drug is consumed orally it takes a first pass into the liver so that only a portion of it actually gets into the blood stream.

In most cases, the first pass of Winstrol will take place in the gut and the liver. After it has been metabolized it will enter the bloodstream. Any blood that is metabolized in the gastrointestinal tract won’t go directly to the heart. Instead it passes from the liver to the hepatic vein through the portal vein. The liver is the system in your body responsible for filtering excess nutrients, toxins, and various substances that shouldn’t be in your bloodstream.

Oral steroids including Winstrol must first make a pass through the metabolism in the intestines and then again in the liver. Some of the various oral steroids are able to be absorbed intact while others are absorbed after metabolic activity has taken place. During the first pass is completed the drug is allowed to move through the body until another tissue absorbs it.

You will find some huge differences between the body’s reaction to the injectable and the oral methods of consuming Winstrol. The injectable option allows it to be placed directly into the bloodstream so it only has to go through the second pass metabolism while the oral version has to go through the gut and the liver before it is circulated into the bloodstream.

If you choose to inject Winstrol you will get more nitrogen retention than taking the oral version. This allows more muscle tissue to grow. If that is your goal then of course you will want to use the injectable method. They oral method does offer some good advantages though. Taking this first pass though allows the drug to be exposed to various enzymes and proteins.

To help you understand they synergy between Winstrol and the other steroids out there let me offer you some information on Sex Hormone Binding Globulin (SHBG). This is a Glycoprotein that is produced in the liver. More than half of the testosterone in your body is actually SHBG, and you can lower the amount of it when you consume Winstrol. A dose as low as .2mg per kg of body weight will help you reduce the amount of SHBG by 50%.

You may be wondering why you can’t get the same results with the oral method. This is because of the first pass it has to take through the liver. The Winstrol interacts with SHBG that is produced in the liver. It doesn’t go through the bloodstream first. Studies have shown that the injectable method of Winstrol is more effective than the oral when 700 mgs are injected per week vs. 400 mgs per week consumed orally.

For women, the opposite is true – they need to use the injectable method of Winstrol. The oral version offers need more synergy in their cycles but women want to avoid this. When women have less SHBG they have more testosterone and that can lead to hirsuitism which is an abnormal growth of body hair. It can also affect their menstrual cycle. Some women find their clitoris becomes enlarged and they suffer from severe acne when they use the oral method of Winstrol.

It is common for males who use the oral method of Winstrol to have more acne as well. Both men and women need to watch for liver toxicity issues as well. This steroid has one of the highest occurrences of that. The best advice I can give you is to use Winstrol if you like, but don’t use too much of it and don’t use it too often.

Friday, August 8, 2014

Alcohol's Effects on Testosterone

The majority of research conducted in the past 25 years, in both animals and humans, has found that alcohol inhibits testosterone secretion. However, a new study found that alcohol can induce a rapid increase in plasma and brain concentrations of testosterone in some rodents. "We have demonstrated that there are very different results in the way two different groups of male rats form testosterone after acute administration of alcohol," said Robert H. Purdy, senior staff scientist in the department of neuropharmacology at The Scripps Research Institute and senior author of the study. "These differences in animals may reflect similar individual differences in humans, and provide new insights for understanding individual differences in the behavioral and endocrine pathology associated with alcohol abuse."

According to the ACER report: Researchers "injected either alcohol or 1,1-dideuteroethanol (2 g alcohol/kg body weight) into the abdominal cavities of two groups of rats, 30 un-operated and 24 adrenalectomized and castrated (ADX/GDX) Wistar males. 1,1-dideuteroethanol is a nonradioactive form of alcohol in which two of the hydrogen atoms on carbon atom #1 of ethanol have been replaced by deuterium atoms, which can then be traced."

They then used mass spectrometry to determine both the amount of neuroactive steroids present and the degree of deuterium in specific neuroactive steroids isolated from brain samples.

The resarchers found that concentrations of testosterone increased fourfold in the frontal cortex and threefold in the plasma of the un-operated rats 30 minutes after alcohol administration. ADX/GDX rats had testosterone concentrations that were only five percent of those found in the un-operated rats after alcohol injection. The findings demonstrated that alcohol oxidation is directly linked to testosterone biosynthesis, the authors said.

"Our finding of a direct link between alcohol administration and the level of the neuroactive steroid testosterone in the brain of these experimental animals was unanticipated from prior studies with another species of rats," Purdy said.

"Although many other studies clearly demonstrate that chronic consumption of high dosages of alcohol appears to be consistently inhibitory and suppresses reproductive function," said Dennis D. Rasmussen, research associate professor in the department of psychiatry at the University of Washington, "this study raises the possibility that episodes of alcohol consumption may also at least temporarily increase testosterone levels, with the direction of the response likely being dependent upon a variety of factors, including dosage and personal characteristics.

"This particular dosage produced blood alcohol levels and behavioral responses consistent with intoxication. So, alcohol consumption, under at least some conditions and by at least some individuals, may acutely stimulate testosterone levels in the plasma and brain of both males and females and thus could elicit some of the behavioral effects associated with increased testosterone levels, such as increased libido or aggression."

Rasmussen said, his findings join those of two other studies in which alcohol administration increased plasma testosterone levels in a gender- and dose-dependent manner. "Together these studies are important," he said, "because they illustrate that what has become a largely accepted principal - that alcohol consumption inhibits plasma testosterone levels and reproductive function - is not universally true."

Rasmussen suggested that future research build upon and add to previous findings regarding alcohol's effects on testosterone. "It would be important to determine whether lower dosages of alcohol, which do not induce rapid pronounced intoxication and ataxia, would also produce the acute increase in testosterone, and whether this response to lower dosages would be consistent across different strains of rats. Also, does tolerance develop with repeated administrations?

"Does this increase in testosterone occur following elective self-administration of alcohol? Finally, and probably most interesting, what role might the demonstrated changes in testosterone play in behavioral responses to acute ethanol consumption? Are there gender differences in these responses? And, if the responses do occur in females, are they different during different stages of a woman's cycle?"

Thursday, July 31, 2014

Enanthat 250 by Dragon Pharma

Enanthat 250 by Dragon Pharma is an injectable steroid which contains 250mg per ML of the hormone Testosterone Enanthate.

The Enathate ester of this drug makes its release into slow and therefore is requires injections to be less frequent than they would be if a bodybuilder using Propionate.

Testosterone is the most common anabolic hormone that there is and is also considered the most basic. Due to this, bodybuilders often consider it the base steroid to most all cycles. Testosterone is both anabolic and androgenic in nature. Users of this steroid will notice a dramatic gain in muscle size and strength, as well as an overall sense of well being and increases libido and sex drive.

Testosterone aromatizes very easily and therefore estrogen buildup and side effects can become an issue for users sensitive to these problems or those choosing to use a high dose of this compound. Therefore, when using Testosterone, bodybuilders often choose in incorporate an anti-estrogen such as Anastrozole, Proviron, Tamoxifen to help keep estrogen related side effects to a minimum. Extremely sensitive users, or users using very high doses (800-1200mgs) might find that stronger anti-estrogens such as Letrozole or Exemestane are more suitable. Androgenic side effects such as oily skin are also possible while taking Testosterone.

Bodybuilders looking to bulk up, often stack Testosterone Enanthate with other steroids such as Nandrolone Decanoate and/or Boldenone, along with an oral compound such as Dianabol or Oxymetholone. Those Bodybuilders looking to use testosterone during cutting phase, might wish to stack it with compounds such as Trenbolone, along with an oral like Stanozolole or Oxandrolone.

Testosterone use will quickly shut down the body's natural production of the hormone, thus making a proper PCT plan essential for restoring the body's natural function and maintaining gains as best as possible after use of the steroid has been discontinued. At cycle's end, bodybuilders often choose to use a combination of Clomid, Tamoxifen, and HCG for a period of 3-4wks in order to restore pituitary gland and testes operation quickly and effectively.

Woman bodybuilders often use testosterone to build mass, although of course the dosage is significantly less than what males would use due to the possibility of masculizing side effects.

The male bodybuilder's dosage of this steroid would typically be in 500-1250mg per week range and cycle duration would be from 8-20 weeks, depending of course on the goals of the athlete. Women typically see desirable results from doses of 50-100mgs per week.

Friday, July 25, 2014

Exemestane makes you slimmer and more muscular

Exemestane, the active ingredient in Pfizer’s Aromasin,  truly is a body recompositioning drug. At least it is if you’re prepared to accept the results of an Italian study in which 33 women used exemestane for a period of 2 years.

Exemestane is an aromatase inhibitor with a steroid skeleton. Apart from the ethyl group on C6, the compound bears a striking resemblance to Boldenone. If the enzyme aromatase – which converts androstenedione and testosterone into estradiol – tries to provide exemestane with an aromatic ring, it gets so stuck that it breaks down. This is how exemestane lowers oestrogen levels.

Once women with an estradiol-sensitive form of cancer have undergone chemotherapy, an operation and radiation therapy, they usually take anti-oestrogens for five years after that. Most take nolvadex for a couple of years and then go over to an anti-oestrogen like anastrazole or exemestane. Little is known about the long-term effects of exemestane, hence the Italian research.

The researchers monitored 68 older women for 2 years. All the women had already been taking 20 mg nolvadex daily for 2-3 years. Half of them continued with this and the other half started taking 25 mg exemestane per day instead.

The exemestane group built up lean body mass. In the two years that the trial lasted the women in that group gained an average of 2.2 kg lean body mass. And the same group lost an average of 0.7 kg fat.

The triglyceride levels in the blood of the women in the exemestane group went down – a positive development. At the same time exemestane increased the levels of LDL [bad cholesterol] and reduced the concentration of HDL [good cholesterol] – a negative development.

American cancer researchers have offered an explanation of how exemestane might cause these effects. Exemestane itself has almost no androgenic effect, but the researchers announced in 2007 that an exemestane metabolite – the 17beta-hydroxy analogue – is capable of interacting with the androgen receptor.

This means that women should consider carefully whether to use exemestane or not. It also means that exemestane is now of interest to chemical athletes with modest aims.

If men take 25 mg exemestane daily their testosterone level rises by a third, researchers at Farmitalia discovered in the 1980s.

So what would happen if you got men to take 25 mg or 50 mg exemestane daily for a year? And if those men were to do weight training as well?

Friday, July 18, 2014

Women and Trenbolone Use

Trenbolone is one of the most por drugs used by bodybuilders today and, when you look at the stats, it is not hard to see why. A very potent androgen with strong anabolic activity, Trenbolone is an extremely effective hardening and cutting agent. In fact, it is considered indispensable when it comes to pre contest preparation. However, it is also extremely valuable in the off-season as it creates a rapid build up of strength and muscle mass. In fact, the anabolic effect is often compared to testosterone or Dianabol with one very important difference - it does not convert to estrogen. This is what truly sets it apart, as most mass building drugs readily aromatize, leading to many estrogen related problems (e.g. water retention gynecomastia).

Due to the lack of water retention, the gains when using this drug are more easily maintained on discontinuing its use. In addition to this, a very hard and defined appearance can be achieved. Also, since gynecomastia is not an issue, there should not be any need to add an anti-estrogen as long as Trenbolone is the only steroid being used. Due to the highly androgenic nature of this drug an increase in the burning of body fat is observed and a much tighter physique can be achieved without having to resort to extreme dieting.

Trenbolone is more potent than testosterone with an effect being gauged as three times as strong on a milligram for milligram basis. It is also four times as anabolic as Deca-Durabolin - nandrolone decanoate - Durabolin and ten times as androgenic. This makes the majority of the weight gained on this drug lean, quality muscle. Trenbolone also creates an increase in the levels of the hormone IGF-1 (Insulin like Growth Factor-1) which is highly anabolic within muscle tissue. Trenbolone has a stronger binding affinity to the androgen receptor than testosterone. This feature is a major contributing factor to the process of anabolism and fat loss. By promoting nitrogen retention and protein synthesis within the muscle Trenbolone allows the food you eat and the nutritional supplements you take to be used more effectively. It also reduces levels of the catabolic hormone cortisol. Trenbolone is also involved in the production of red blood cells and increases the rate of glycogen replenishment (both of which contribute not only to stamina but also to recovery from workouts)

A reduction in aerobic capacity is the most common complaint with Trenbolone. This is thought to be caused by bronchial dilation resulting from an increase in prostaglandin production. The condition known as "trenbolone Cough" is often a complaint registered with users of the Acetate version (Trenbolone is available in Acetate and Enanthate forms). Androgenic side effects may also be experienced which include oily skin, aggressive behavior, and acne and hair loss. For this reason women are usually advised to stay away from this drug.

It seems that although women are generally told to avoid using this drug, Trenbolone is being used more and more by women in controlled doses. The fact that it adds primarily lean mass whilst reducing body fat is obviously a key factor in its attractiveness. When women were asked for their feedback on Trenbolone use a variety of favored dosages came up. Anything from a very conservative 10mg every other day to a more adventurous 100mg/week split into two doses.

Stacking Trenbolone with Testosterone Propionate was also something favored by those engaging in high level competition. Another use of Trenbolone involved taking it 3-4 days before a show in order to add hardness and definition to the physique. It has to be said that side effects were experienced by all - usually increased hair growth and acne - and the severity of the side effects seemed to be worse in younger women. The theory expressed here being that ovarian function may be the reason for this, with a younger woman still having stronger ovarian function than an older women who may be entering peri-menopause. This is all speculation of course but seems like a plausible explanation in my opinion. Either way, if you are considering using Trenbolone it is advised to use it on its own and at extremely low doses (such as the aforementioned 10mg every other day) in order to test your own unique sensitivity.

Trenbolone is a potent androgen that is primarily used in cattle, so there is even less information at our disposal on this compound or its effects on the female endocrine system than any other drug. It is the one drug that seems to produce results as significant as the side effects that are associated with it. Women are generally advised to stay clear of Trenbolone considering the strong androgenic component which eradicates any possibility of running Trenbolone without sides. The more seasoned female athlete will run it in the off season in order to reap the muscle building benefits of the drug whilst maintaining a relatively low body fat. On the other hand running it during contest preparation will preserve the newly added muscle mass while on a calorie restricted diet. The less daring athlete will run Trenbolone during the last few weeks of contest preparation or even limit their use to the week before the show - with a more frequent injection schedule.

Women who have experienced less favorable side effects on Trenbolone report experiencing tachycardia from a single pin, accompanied by profuse night sweats and insomnia bad enough to bail on the cycle. Others experience rapid hair growth with more frequent shaving (side effects that are far from unmanageable).

Quite honestly, Trenbolone dosing is dependent on how much a woman is willing to deal with in terms of sides. There is no conservative dose for a first timer with Trenbolone being far better suited for the educated, experienced and seasoned athlete who has paid her dues.

It is also important to note that Trenbolone lowers TSH levels so running T3 in conjunction with it is highly advisable, as well as an anti-prolactin such as Dostinex at 0.5mg every third day or 5mg of Bromocriptine daily to keep prolactin levels in check.