Friday, April 11, 2014

Proviron (mesterolone)

Proviron is an oral DHT steroid compound similar to Masteron. Although it is not an ideal compound for building muscle (actually it is not good at all for this purpose), Proviron is helpful in stacks because of its unique ability to keep the body from turning testosterone into estrogen, thus giving the testosterone a better anabolic effect. This aids the bodybuilder in many ways. First, it helps reduce estrogenic side effects of other steroids water-retention, lowered sex drive, gynocomastia, etc. Also, Proviron can help boost the potency of testosterone in the body by freeing testosterone from its binding to sex hormone-binding globulin.

Proviron is therefore best stacked with testosterone, which makes taking anti-estrogen compounds unnecessary. However, Proviron can cause high blood pressure so blood pressure medication may be required for those prone to hypertension.

Proviron is the Schering brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. Proviron does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.

Although Proviron is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as sex hormone-binding globulin, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an anti-estrogen. It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced.

The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.

Proviron is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol, oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. Proviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).

The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, Proviron is often used throughout the entire cycle. As mentioned earlier, it is often combined with Nolvadex (tamoxifen citrate) or Clomid (clomiphene citrate) when heavily estrogenic steroids are being taken (Dianabol, testosterone etc.). Administering 50mg of Proviron and 20mg Nolvadex daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.

Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a “safe” oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on Primobolan (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.

The popularity of Proviron amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Proviron is now very easy to obtain on the black market. Most versions will be manufactured by Schering, and should cost about $1-$2 per 25 mg tab. This drug is packaged in both push-through strips and small glass vials, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex, Femara, or Aromasin ares actually a much better choice than Proviron though. These drugs were designed specifically as an anti-aromatase, and works much more effectively than anything else we have available.

Thursday, April 3, 2014

How Anabolic Steroids Work in your body

Most people who are close-minded only think of the negative effects of anabolic steroids. Many despise body builders or athletes who take anabolic steroids just to get faster results or becoming bigger and stronger. What’s interesting is that our body naturally produces anabolic steroids through the male hormone, testosterone. And if you actually have natural steroids in you, then why should people condemn those who are taking them for their own purposes?

The fact is anabolic steroids are actually very helpful especially to patients in hospitals who have lost amounts of body tissues due to chronic wasting. These supplements can help build not only muscles for bodybuilders or endurance for athletes, but they can also help build tissues for medical patients who need to have faster recovery for the tissues lost.

Steroids are lipids from cholesterol in the body, which is secreted by various glands. The anabolic steroids that are typically used in bodybuilding are actually synthetic derivatives of the male hormone, testosterone, which promotes the growth of bones and muscles.

Since anabolic steroids come from testosterone, it has the same effects as this male hormone. Like the testosterone, which is produced in a man’s testicles, steroids have also anabolic and androgenic effects. The former is the primary target of both athletes and bodybuilders.

Anabolic steroids have been a huge part in bodybuilding and used mostly for their advantages such as anabolic benefits including the increase of muscle strength and size, increase of energy levels during activities, for faster recovery time and to increase the oxidation rise of fat. What anabolic steroids do is that they increase the testosterone levels in the body without passing through the usual pathway for the synthesis of the hormone by directly adding testosterone into the bloodstream. Generally, anabolic steroids are used for increase in muscle mass. However, the anabolic and androgenic benefits of these supplements actually still depend on the steroid type used. Increasing the male hormone in one’s body does not exactly cause chemical reactions. However, this just basically amplifies the reactions that already exist between your body and the male hormone.

Anabolic steroids are basically “man-made” testosterone chemically altered to optimize the anabolic effects with the minimum androgenic consequences as possible. We ourselves produce steroids inside our body so what you will only be doing if you take in some more steroids is to increase its effects. However, even the best anabolic steroids have certain side effects especially when taken in at huge doses. In the end, it always goes down to discipline and how you take anabolic steroids moderately. If you abuse anabolic steroids, you might get the side effects that all people are afraid of. But if you follow directions and control your urge to want some more steroids for more benefits, then steroids may not be so bad for you. As long as discipline is integrated in your anabolic steroids intake, then not only can you finally get the body as well as the energy that you desire, you can also have a positive change in your mood and sleep patterns, prevent depression and symptoms of arthritis as well as have your bones strengthened.

Because of these benefits, steroids have become a very significant part in athletics as well as in bodybuilding. In fact, it almost seemed like bodybuilding is synonymous to anabolic steroids. But other than these two pursuits, anabolic steroids can also be used with other strenuous hobbies such as dancing, wall climbing, etc., so that you can have a better endurance and an increased level of energy during these activities. Because of this, people are able to train more, and thus improve more on what they are best at.

Wednesday, March 26, 2014

Anadrol - “The Classic Mass-Builder”

“Mass”…the defining attribute of a bodybuilder. It is the term on which bodybuilding itself is built and the quality that sets us apart from all other athletes. We all seek it and we can never have too much of it. There are many steroids which can help us in our acquisition of muscular size, but few steroids which are optimally suited for this purpose. Welcome to Anadrol - the anabolic steroid that for decades stood as the #1 mass-builder in all of bodybuilding.

Anadrol is the brand name for the anabolic steroid Oxymetholone, which was originally developed in 1960 by the drug company Syntex. It’s original and primary purpose was for the treatment of anemia, due to Anadrol’s ability to significantly stimulate the production of red blood cells in the body. Anadrol was also indicated for those suffering from osteoporosis and less frequently, for the growth of malnourished or undeveloped patients.

Anadrol is one of many drugs included in the category of compounds known as oral anabolic steroids. Oral steroids are anabolic-androgenic hormones which are most often molecularly altered at the 17th carbon position by the attachment of a methyl group, which allows the drug to maintain structural integrity as it passes through the digestive tract and eventually into the blood stream. In the absence of this molecular modification, the anabolic steroid would be subsequently destroyed in the liver and rendered useless prior to reaching its target tissues. However, the resultant effects of methylation are not limited solely to that of a protective mechanism, as it also plays a role in determining the effects of the drug itself through the alteration its chemical make-up. Therefore, the process of methylation results in a completely new steroid with its own unique set of characteristics. In the case of Anadrol, we are left with a compound that demonstrates potent anabolic activity, while maintaining a unique and somewhat intriguing metabolism in the world of anabolic steroids.

According to Vida - Anadrol maintains an anabolic/androgenic ratio of 320:45, making it 3.2X more anabolic than testosterone, yet less than half as androgenic per mg. This gives Anadrol a higher anabolic rating than many other steroids in its class, such as Dianabol and T-bol. Now, while Anadrol’s A:A ratio is relatively straightforward, it’s metabolism and mechanisms of action are a bit more of a mystery. When evaluating a steroid such as testosterone, its metabolism is clearly understood, but with Anadrol we are looking at a steroid which does not result any progestagenic activity, does not convert to DHT, nor does it aromatize to any degree, yet it is notorious for exhibiting a slew of side effects associated with all of these metabolites.

In an attempt to reconcile Anadrol’s estrogen-like activity with its inability to aromatize, a few theories have been put forward in recent years as an explanation for this discrepancy, yet to my knowledge, no one has yet put the final nail in the coffin with supporting scientific research. The first of these theories suggests that the Anadrol molecule itself demonstrates estrogenic activity by directly attaching to and interacting with the estrogen receptor. This explanation would suffice if it was true, but the problem is that there has not been any scientific research supporting this theory, let alone confirming it. Some others have speculated that Anadrol may act as a progestin, although a medical study examining this theory found there was no such progestagenic activity present. A 3rd theory proposes that Anadrol may elicit this effect through its ability to lower serum levels of SHBG, which would consequently displace previously bound estrogen and release it into free circulation where it could then exert its effects. With Anadrol having been shown to lower serum levels of SHBG in the literature, this theory is certainly plausible.

Regardless of the working mechanism(s) responsible, there is no doubt that Anadrol is capable of inducing all of the typical estrogen-related side effects, and when administered in conjunction with an aromatizable drug, it often does so in pronounced fashion. Without instituting preventative measures, users may experience side effects such as: gynecomastia, subcutaneous water retention, elevations in blood pressure, and bloat, to name a few.

The standard treatment option for managing estrogen levels when using aromatizable drugs is through the concomitant use of an AI, but with Anadrol being unaffected by the aromatase enzyme, the question arises as to what treatment option is the most effective. While on the surface it may appear that AI treatment is not a viable alternative, user experience has repeatedly shown that this class of drugs is efficacious in circumventing the estrogen-like effects of Anadrol. Whether this occurs through a reduction in previously circulating estrogen, a different mechanism(s) altogether, or a combination of the two, it is unclear. Regardless, AIs are effective in minimizing/preventing Anadrol’s estrogen-like activity. In cases where the estrogen-like effects of Anadrol have acutely manifested (example: gyno), a serm such as Nolvadex remains the preferred course of action.

As mentioned above, Anadrol is not capable of converting to DHT, but like all steroids, it maintains the ability to increase the rate at which male pattern hair loss occurs in those who are prone. While it is impossible to give an accurate estimate regarding the percentage of users who might encounter this side effect, I will reluctantly state that this drug probably falls somewhere between Winstrol and Testosterone, in terms of its potential to hasten hair loss. For those anabolic steroids users who place a higher premium on keeping a full head of hair over sheer muscular size, they might do well to remain cognizant of this possibility when deciding whether or not Anadrol should be a part of their future cycles.

Another area where Anadrol distinguishes itself from many of its chemical cousins is in the realm of receptor binding relative to myotropic potency. Oxymetholone binds very weakly to the AR, so weakly in fact that its binding affinity is barely measurable, yet it remains one of the most potent oral steroids on the market for the acquisition of muscle mass. This is in direct contrast to a drug such as Trenbolone, which is also very proficient at muscle-building, but which exerts the majority of its effects through the signaling of the AR (androgen receptor). With Anadrol being incapable of activating the AR to any meaningful degree, there has been speculation of Anadrol relying predominantly on non-genomic mechanisms in order to effectuate muscle growth. There is some science available to support this claim, but we still have a long way to go in this area of steroid research before we have anywhere close to a complete understanding.

Whenever discussions of oral anabolic steroids come up, one area of interest frequently mentioned is that of liver toxicity. Being a methylated steroid, Anadrol is no exception to this and with good cause. Perhaps more than any other anabolic steroid, Anadrol has a long history of causing a variety of medically documented health problems when abused. Some of these noted health problems include: Cholestatic hepatitis (inflammation of the liver), Peliosis hepatis (blood-filled liver cysts), liver tumors, jaundice, Hepatic necrosis, and death. While these side effects are rare when Anadrol is properly administered, the potential for harm exists when abused for long periods of time and/or when utilizing excessive dosages.

Fortunately, most bodybuilders today understand the need for proper cycling and with the inclusion of various liver and other health aides playing a role in the programs of today’s bodybuilders, we are less likely than ever to experience these health problems. In reality, many of the toxicity claims are grossly over-exaggerated. While I certainly do not want to portray myself as one with a reckless attitude, it is important to see things as they really are. Caving in to over-blown fears (or maintaining a vigilante attitude) doesn’t do anyone good. While oral anabolic steroids are capable of causing toxicity issues, when utilized responsibly, they are a relatively safe category of drugs.

In years past, it was common to see bodybuilders running cycles of Anadrol or Dianabol for 8-10 weeks in length (or more), but in recent times it seems many bodybuilders are afraid to run any oral anabolic steroids for longer than 4-6 weeks. This mentality began to pervade the online bodybuilding community at around the mid-point of the current PH/Designer marketplace boom. Due to most OTC manufacturers recommending that their products be run for no more than 3-6 weeks, bodybuilders began to follow suit and apply these guidelines to other oral anabolic steroids. While prudence can be a virtue, the truth is that many oral anabolic steroids can be run for a significantly longer period of time with a relatively high degree of safety.

Even Anadrol itself, which was long considered one of the most toxic oral anabolic steroid, underwent considerable university research before being approved for human use. After becoming a legitimate prescription drug, patients were regularly prescribed treatment plans involving several months of usage at dosages between 50-150 mg/day. Despite Anadrol’s repeated toxicity claims, physicians persisted in recommending these treatment plans for decades with very few serious problems.

The half-life of Anadrol is around 8.5-9 hours, necessitating 2-3X daily dosing if blood levels are to be kept relatively stable. The most common dosing scheme employed today ranges from 50-100 mg per day, which is more than capable of supplying impressive increases in size & strength. Few users will ever need to exceed this dosing amount. Some more adventurous users have been known to go up to 150-200 mg per day and a small percentage of individuals (who apparently have a grudge against their liver), have gone as high as 500+ mg per day. I see little reason to exceed 100-150 mg per day, as further benefits will be minimal and the likelihood of experiencing side effects rises. Some of these side effects may include: appetite suppression, lethargy, general malaise, headaches, acne, aggression, increased and/or decreased sex drive, among others.

The standard cycle length for Anadrol ranges between 2-10 weeks in length. Some users choose to use it for short blasts at the onset of their cycle in order to get gains moving along quickly, while others will choose to run it for a longer period of time. In terms of real-world effects, Anadrol is one of the very best mass & strength builders around. It is beloved in both the bodybuilding and strength communities and is used in both off-season mass-building cycles, as well as pre-contest cycles in order to assist the bodybuilder in maintaining size and fullness while in a caloric deficit. Weight gains ranging between 15-25 pounds in 4-6 weeks are not uncommon, but these gains in mass tend to fall off as rapidly as they were acquired after cessation of the drug. This is definitely not a compound one would use for long-term mass retention. Anadrol will make you massive and strong while you’re taking it, but that is where it ends. The user should also expect a fair degree of their weight gain to come in the form of water retention, both intramuscular and subcutaneous. This effect, while typically not visually appealing, contributes to pain-free lifting for many users. Anadrol has also acquired a reputation for delivering huge pumps during workouts, even to the point where some users claim they are debilitating to the point of stopping their training session. At any rate, there is no doubt that Anadrol excels in this area.

In conclusion, Anadrol is powerful, all-out mass & strength drug which when respected, can safely be used to deliver some of the quickest gains of any anabolic steroids in the world. While you may not look pretty when using this drug, you will certainly come to understand the meaning on the word “ON”.

Friday, March 21, 2014

Nolvadex vs. Clomid

It seems like everyday questions concerning Post Cycle Therapy pop up, and weather one should use either Clomid or Nolvadex or a combo of both. I hope that this article may help to clear up some misconceptions.

While practically similar compounds in structure, few people ever really consider Clomid and Nolvadex to be similar. Its not just a common myth in steroid circles, but even in the medical community. This misconception originates from their completely different uses. Nolvadex is most commonly used for the treatment of breast cancer in women, while Clomid is generally considered a fertility aid. In bodybuilding circles, from day one, Clomid has generally been used as post-cycle therapy and Nolvadex as an anti-estrogen.

But as I intend to demonstrate this is in essence the same. I believe the myth to have originated because Nolvadex is clearly a more powerful anti-estrogen, and the people selling Clomid needed another angle to sell the stuff, so it was mostly used as a post-cycle aid. But few users really understand how Clomid (and also Nolvadex, logically) works to bring back natural testosterone in the body after the conclusion of a cycle of androgenic anabolic steroids. After a cycle is over, the level of androgens in the body drop drastically. The body compensates with an overproduction of estrogen to keep steroid levels up. Estrogen as well inhibits the production of natural testosterone, and in the period between the return of natural testosterone and the end of a cycle, a lot of mass is lost. So its in everybody’s best interest to bring back natural test as soon as humanly possible. Clomid and Nolvadex will reduce the post-cycle estrogen, so that a steroid deficiency is constated and the hypothalamus is stimulated to regenerate natural testosterone production in the body. That’s basically how the mechanism works, nothing more, nothing less.

Both compounds are structurally alike, classified as triphenylethylenes. Nolvadex is clearly the stronger component of the two as it can achieve better results in decreasing overall estrogen with 20-40 mg a day, than Clomid can in doses of 100-150 mg a day. A noteworthy difference. Triphenylethylenes are very mild estrogens that do not exert a lot, if any activity at the estrogen receptor, but are still highly attracted to it. As such they will occupy the receptor and keep it from binding estrogens. This means they do not actively work to reduce estrogen in the body like Proviron, Viratase or arimidex would (by competing for the aromatase enzyme), but that it blocks the receptor so that any estrogen in the body is basically inert, because it has no receptor to bind to.

This has advantages and disadvantages. The disadvantage is that when use is discontinued, the estrogen level is still the same and new problems will develop much sooner. The advantage is that it works much faster and has results sooner than with an aromatase blocker like Proviron or Arimidex. Therefor, when problems such as gynocomastia occur during a cycle of steroids one will usually start 20 mg/day of nolva or 100 mg/day of Clomid straight away, in conjunction with some Proviron or arimidex. The proviron or arimidex will actively reduce estrogen while the Clomid or Nolvadex will solve your ongoing problem straight away. This way, when use is discontinued there is no immediate rebound.

So which one should you use? Well personally, I’d have to say Nolvadex. Both as an on-cycle anti-estrogen and a post-cycle therapy. As an anti-estrogen its simply much stronger, demonstrated by the fact that better results are obtained with 20-40 mg than with 100-150 mg of Clomid. For post-cycle, this plays a key role as well. It deactivates rebound estrogen much faster and more effective. But most importantly, Nolvadex has a direct influence on bringing back natural testosterone, where as Clomid may actually have a slight negative influence. The reason being that Tamoxifen (as in Nolvadex) seems to be the best choice for Post Cycle Therapy.

Thursday, March 13, 2014

Vitamin C and E protect testes during steroids cycle

A small group of doping users combine antioxidants such as vitamin C and E with their anabolic steroids. The idea behind this supplementation is that the antioxidants protect the testes while steroids are being taken, helping the body’s own testosterone to kick in faster at the end of the course. Not such a crazy idea, according to the results of an animal study that researchers at the Comenius University in the Slovak Republic.

When athletes put anabolic steroids into their body, they reduce their natural Testosterone production. When done in an intelligent way, the effect is temporary. Long-term use of high doses without breaks is another matter… and not intelligent.

Endocrinologists regularly see older men who have become infertile after years of using steroids, or whose testosterone production has become exceedingly low, despite the improved post-cycle therapy forms now popular in the steroids scene.

The researchers at Comenius University performed experiments with rats to try and better understand what happens in the testes during a course of androgen supplementation. They gave a group of rats an injection containing 5 mg testosterone isobutyrate per kg bodyweight every other day.

Other groups of rats were given injections containing the anti-androgen cyproterone or injections containing both testosterone isobutyrate and cyproterone, or injections containing no active ingredients at all.

After two weeks the researchers analysed the rats’ testes. As you’d expect, the rats that had been given testosterone isobutyrate produced less of their own testosterone.

Administering testosterone, with or without cyproterone, boosted the concentration of thiobarbituric acid reactive substances in the testes. These are released when aggressive molecules attack unsaturated fatty acids in cell membranes.

At the same time, the total amount of antioxidants in the testes of the rats that had been given testosterone had decreased, and the amount of advanced glycation end products had increased.

Advanced glycation end products are created when glucose attaches itself to amino acids, forming inactive complexes. The tissues are often incapable of clearing up the AGEs, and as a result the AGEs impede the tissues’ functioning. This effect may have something to do with the lasting negative long-term effects of steroids use we mentioned above. We’re just hazarding a guess here.

The notion of consuming vitamin C and E antioxidants or super foods with a high ORAC value during a course of steroids isn’t such a strange idea at all after reading the Slovakian study. What’s more, you wonder to what extent a low-carb diet might also protect anabolic steroids users’ testes.

Friday, March 7, 2014

Trenbolone use in bodybuilding

These days, there probably isn’t a bodybuilder alive that hasn’t heard of Trenbolone. In today’s drug circles, it has attained nearly super-hero status as an anabolic agent. “Nectar of the gods”…“A steroid on steroids”…and “indispensable” are just some of the terms which have been used to describe this highly desirable drug. There is no single characteristic responsible for Trenbolone’s unique effects on the musculature. Rather, it is a precise combination of attributes which provide such amazing results.

There are few non-methylated drugs capable of functioning as both a mass builder and cutter, while excelling at both. In fact, if pressed to name another non-methylated drug capable of duplicating trenbolone’s performance. Typically, Trenbolone is known for its ability to generate substantial gains in dense, dry muscle tissue; a trait which has no doubt earned it a top spot in both contest prep and off-season programs alike. Likewise, its strength building and psyche altering capabilities have made it popular among strength-power athletes, but rather than re-hash these well known traits, I want to spend a bit of time talking about some of the less publicized qualities of Trenbolone.

One often debated topic in the steroid world is the role of estrogen in the muscle growth process. Up until the last decade, many bodybulders were taught to avoid the use of anti-estrogenic drugs when in the off-season, as it was commonly believed that the elevated estrogen level achieved with aromatizable drugs was necessary for maximizing muscle growth. This belief was born out of real-world experience, with many bodybulders noting a reduction in overall weight gain when administering these drugs. Were these old-school bodybulders simply confusing estrogen induced water retention with genuine muscle growth, or was there more to the story? In recent years, the phobia surrounding anti-estrogenic drugs has greatly diminished. While science has confirmed the importance of estrogen in the growth process, most steroid users now believe that keeping levels within the low-normal range is more than sufficient to obtain all its growth benefits. To this end, aromatase inhibitors such as Aromasin and Arimidex are freely employed in the programs of today’s steroid using bodybulders. So, how does this apply to trenbolone, a non-aromatizing steroid, you might ask?

In recent years, the phobia surrounding anti-estrogenic drugs has greatly diminished. While science has confirmed the importance of estrogen in the growth process, most steroid users now believe that keeping levels within the low-normal range is more than sufficient to obtain all its growth benefits. To this end, aromatase inhibitors such as Aromasin and Arimidex are freely employed in the programs of today’s steroid using bodybuilders. So, how does this apply to trenbolone, a non-aromatizing steroid, you might ask?

Trenbolone may also stimulate growth through enhanced proliferation and differentiation of satellite cells, which may be mediated through an increase in IGF-1 sensitivity. In order to understand why this is important, let’s first look at the role of satellite cells in the muscle growth process. After a hard training session, the muscle cell proteins within muscle fibers sustain damage, which activates a special type of stem cell known as satellite cells. These cells, which are located between the basal lamina and plasma membrane (an area directly outside the muscle fibers), are quickly shuttled to the site of injury, initiating the muscle regeneration process. They then begin to multiple (proliferate) by fusing to other satellite cells and to existing muscle fibers. A portion of these satellite cells will remain as organelles, but the majority will differentiate (the process of turning immature stem cells into mature muscle cells) and fuse to muscle fibers, either creating new muscle protein stands (myofibrils) or helping to repair previously damaged muscle fiber. The formation of these myofibrils (muscle fibers) directly leads to an overall increase in the size of the muscle.

This muscle repair process is aided by numerous growth factors, such as testosterone, growth hormone, insulin, IGF-1, HGF, and FGF. These hormones influence the rate and amount of protein that is deposited in the muscle during the repair process, with higher levels speeding up the muscle growth process and lower levels slowing down the process. In particular, IGF-1 and FGF have a direct influence on the proliferative response of satellite cells. In multiple studies, trenbolone has been shown to enhance this proliferative response, which the researchers suggest is due to trenbolone’s ability to increase satellite cell sensitivity to IGF-1.

Friday, February 28, 2014

Effects of Testosterone

Testosterone is a steroid hormone and it belongs from the group of androgen. It is the hormone found in birds, mammals and vertebrates. In mammals, ovaries of females and testicles of males secrete testosterone. Testosterone is the sex hormone in male and a basic anabolic steroid as well. Testosterone has its significance in the male reproductive tissues in which testis and prostate are included and it deals with the growth of the hair of the body. It is an essential component for health and well-being of a person.

Normally concentration of testosterone is greater in adult males as compared to females and it is nearly believed to be 7-8 times greater. Normally, the female body is more receptive and sensitive to hormones. It is the hormone, which is present in most vertebrates including the fish. That is the reason why Testosterone is an essential part of the body of human as well as other mammals and vertebrates.

Testosterone provides both the virilizing as well as the anabolic effects and some effects are considered both, as it is very difficult to make a distinction between them. When you talk about the anabolic effects, you see the strengthening of body and muscle mass and linear growth stimulation as well as the bone maturation. The virilizing or androgenic effects deals with the enhancement as well as the maturation of the organs related to sex in which the fetus scrotum and penis is of utmost importance. It also deals with the deepening of the voice, growth of different kinds of hair of the body. Other than these male secondary sex characteristics, they also deal with the postnatal effects in the case of both males as well as females and in that case, they are dependent on the duration of the circulation of the testosterone.

Normally the effects of testosterone are more in male adults as compared to the female adults but they are equally important for both the sexes at the same time. However, it is a fact that testosterone level may decrease in the adult life in the later part.

Among other uses of testosterone, it is the highly important and necessary ingredient for the sperm development in males. This hormone helps in activating the genes in the cells for the differentiation of Spermatogonia. Testosterone provides the physical energy and it maintains the trophism for the muscles. If high androgen levels are found in females, then it makes the menstrual cycle irregular and abnormal and that can happen in the healthy women as well.

Testosterone plays an important role in the maintenance of cardiovascular health. If testosterone level in controlled in the elderly men, then it can decrease the total cholesterol level and decrease fat body mass. It is not known to cause any kind of deleterious effects on the cancer of prostrate. It can play a role in the fight responding time as well. Normally the men who have high level of testosterone are likely to have the high blood pressure and in that way their chances of getting heart attack decreases. However, they are more receptive towards injuries, infections transmitted sexually and other bad habits like smoking.

Along with many other uses, testosterone has its significance in medical use as well. Main use of testosterone is for the treatment of males who have the problem of endogenous testosterone production. This type of disease is known as hypogonadism. In this case, normally the treatment is done through the testosterone therapy in which the replacement is done and then the testosterone levels are maintained in the normal range. However, the replacement therapy may work well for some people, and in other cases, it may cause some problems. It can help in reducing the infertility, it can correct the erectile dysfunction and it can reverse the effects of anemia as well.

Testosterone is effective in giving treatment for the low libido level during the women post-menopausal. Sometimes, the strategies of testosterone are done to prevent loss of bone mass and to deal with any kind of depression. However, some women may face the side effects like increase in their weight and in that case their body fat is not increased but they may face some changes in muscle density. Another risk is that if a woman goes through testosterone therapy then they might face risk of getting breast or any other kind of gynecological cancers up to some extent.

There are many benefits and some adverse effects of testosterone therapy. It can really help in managing the diabetes of type 2. Sometimes, low testosterone level may increase the risk of diseases of high intensity, so therapy is necessary and advised in that case. However, it must important to note that some health risks are also involved with the testosterone therapy and prostate cancer may come apparent after few months of the testosterone therapy treatment.

Testosterone can also be very useful for athletes as well in order to improve their performance drastically. However, it is commonly considered as the doping case in many sports of players use the testosterone. Many other anabolic steroids including the testosterone can be used to strengthen the muscle development. If testosterone is used properly then it makes the fastening repair of the of the muscles fiber.

There are many methods that have been deployed for the detection of testosterone in the athletes and the most common one is the urine test. Among many administration routes for the testosterone the ones that are being used mostly commonly are injectables, buccals, transdermal creams, and some kinds of gels along with few others as well. It is believed that some other methods and nasal sprays will come soon for this purpose.