Facts About Winstrol (Stanozolol)

Stanozolol, commonly sold under the name Winstrol, is a synthetic anabolic steroid derived from dihydrotestosterone. Stanozolol is not esterified unlike most injectable steroids and is available in an oral tablet form or aqueous suspension.

One of the biggest advantages of Stanozolol (also known as Winny) is that it has a high oral bioavailability because of a C17 α-alkylation that allows it to survive first-pass liver metabolism when ingested. If that was not all, Winstrol can be used by both men and women as its anabolic effects predominate over the androgenic effects offered by it, though masculinization and virilization can be common for some users. Medically,Winstrol is used in treating health conditions such as anemia and hereditary angioedaema. It is even indicated for improving muscle growth, production of red blood cells, stimulating the appetite or debilitated or weakened individuals, and increasing bone density.

The chemical name of Winstrol is 17-methyl-2′ H -5(alpha)-androst-2-eno [3, 2- c ]pyrazol-17(beta)-ol and its molecular weight is 328.497 g/mol at the base. The molecular formula of Stanozolol is C22H36N2O and it has an active life of nearly eight to nine days. Oral Winstrol can be detected over a period of three weeks while injectable Stanozolol can be detected over a period of eight to nine weeks.

Sportsmen, especially bodybuilders, stack Winstrol generally with testosterone-based steroids as it leads to dramatic increases in body strength and muscle mass without resulting in excess body weight and fat gain while promoting the levels of vascularity and muscle definition. Furthermore, use of this synthetic anabolic steroid is not associated with excess water retention and many sportsmen even admire the diuretic effects of Winstrol on the body. If that was not all, Winstrol also helps sportsmen, especially those into weight lifting and body building, to preserve lean body mass while metabolizing adipose. Use of this steroid, for a period of six to eight weeks, is associated with dramatic improvements in terms of protein synthesis, nitrogen storage, muscle function, body strength, muscle dimension, and efficiency besides revitalizing prostaglandin E2, fibroblasts, and DNA features.

The recommended dosage of Winstrol (Stanozolol) is 50-100 mg per day (oral form) and 25-50 mg per day (injectable form) for men and 2.5-10 mg per day (oral form) and 2.5-5.0 mg per day (injectable form) for females. Most sportsmen stack it with Dianabol, Halotestin, Testosterone Propionate, Testosterone enanthate, Anadrol, and Primobolan during a steroid cycle of six to eight weeks though some advanced sportsmen even increase duration of the cycle to ten to twelve weeks.

Use of this performance enhancing drug should not be initiated before a qualified medical practitioner has approved its use for legal (medical) purposes after carefully evaluating all medical reports and history. Moreover, this drug should only be purchased from a legal steroid store dealing in legal anabolic steroids and performance enhancing drugs so that one can always be assured of its quality. Abuse of Winstrol or purchase and use of low-grade Winny can lead to side effects such as changes in libido, habituation, excitation, insomnia, hirsutism, increased frequency of erections, male pattern baldness, decreased glucose tolerance, liver dysfunction, clitoral enlargement, and irregular menstruation.

Stanozolol should not be used by pregnant and breastfeeding women, children, or those having an existing allergy to Winstrol or any of its ingredients. It should also not be used by those suffering from health complications such as breast cancer, prostate cancer, heart attack, stroke, and multiple myeloma unless otherwise specifically recommended by the practitioner.

In order to maintain its shelf life and efficacy, Stanozolol should be stored at a controlled room temperature of 20° to 25°C (68° to 77°F) with excursions permitted to 15° to 30°C (59° to 86°F) and must be protected against heat, moisture, direct light, pets, children, and unauthorized use.

Stanozolol by Accordo RX and muscular development

Pharmacology is the study of drugs and their effects. Anabolic pharmacology is the study of drugs that have a growth-promoting effect in muscle. This article will explore anabolic pharmacology by profiling a different anabolic drug and its effects each month. The focus of discussion this month will be the anabolic androgenic steroid, Stanozolol.

Stanozolol is a highly-modified synthetic version of dihydrotestosterone (DHT) that was originally sold under the trade name Winstrol. As you can see, there is an additional ring system attached to the traditional A-ring of the anabolic steroid structure. The binding data for Stanozolol shows it to have very poor binding for the androgen receptor. However, the half-life of nine hours for this anabolic steroid is quite long— making up for the lower affinity. Stanozolol is incapable of being converted to estrogenic metabolites through aromatization, and is already 5-alpha reduced, so it cannot be reduced further— but does seem to have some anti-aromatase activity.

Stanozolol has minimal binding to sex hormone-binding globulin (SHBG), so it circulates for the most part in the ‘free’ state. It has been shown that although stanozolol does not interact directly with the glucocorticoid receptor, it does interact with two glucocorticoid-binding proteins known as STBP and LAGS. This interaction ‘bumps off’ bound cortisol into free circulation. At the same time, Stanozolol has been shown to interfere with cortisol release from the adrenal gland. This results in reduced cortisol levels, with chronic usage. In fact, many people notice severe joint pain when using Stanozolol, especially when used alone. This can result in a rebound effect in cortisol production when going off Stanozolol.

 Even though Stanozolol has a very large anabolic-to-androgenic ratio, it is quite androgenic. The anti-glucocorticoid effect of this drug likely augments its anabolic/androgenic ratio beyond that of its androgen receptor-binding effects alone. Stanozolol decreases thyroxine-binding globulin (TBG) levels but not as much as some of the other common anabolic-androgenic steroids.

 In addition to tablets for oral administration, Stanozolol is available as water-based suspension for injection. Because it is not esterified, this steroid needs to be injected every day. Also, water-based injections are a lot more prone to bacterial contamination, so more care is needed to keep a multi-use bottle sterile. The relatively large crystal size of some preparations limits the size of needle that can be used, because the crystals will jam smaller needles. There are some formulations available that have smaller crystal size; however, these seem to have a shorter half-life— most likely due to the crystals dispersing faster within the muscle.

Because Stanozolol is C-17 alpha-alkylated, it has the potential for liver toxicity— but this is somewhat reduced with the injectable form because a lower overall dose is often used. Stanozolol has a favorable anabolic-to-androgenic ratio, but most do not consider it to be very effective. This is largely due to the fact that Stanozolol does not result in large water weight gains.