Friday, February 28, 2014

Effects of Testosterone


Testosterone is a steroid hormone and it belongs from the group of androgen. It is the hormone found in birds, mammals and vertebrates. In mammals, ovaries of females and testicles of males secrete testosterone. Testosterone is the sex hormone in male and a basic anabolic steroid as well. Testosterone has its significance in the male reproductive tissues in which testis and prostate are included and it deals with the growth of the hair of the body. It is an essential component for health and well-being of a person.

Normally concentration of testosterone is greater in adult males as compared to females and it is nearly believed to be 7-8 times greater. Normally, the female body is more receptive and sensitive to hormones. It is the hormone, which is present in most vertebrates including the fish. That is the reason why Testosterone is an essential part of the body of human as well as other mammals and vertebrates.

Testosterone provides both the virilizing as well as the anabolic effects and some effects are considered both, as it is very difficult to make a distinction between them. When you talk about the anabolic effects, you see the strengthening of body and muscle mass and linear growth stimulation as well as the bone maturation. The virilizing or androgenic effects deals with the enhancement as well as the maturation of the organs related to sex in which the fetus scrotum and penis is of utmost importance. It also deals with the deepening of the voice, growth of different kinds of hair of the body. Other than these male secondary sex characteristics, they also deal with the postnatal effects in the case of both males as well as females and in that case, they are dependent on the duration of the circulation of the testosterone.

Normally the effects of testosterone are more in male adults as compared to the female adults but they are equally important for both the sexes at the same time. However, it is a fact that testosterone level may decrease in the adult life in the later part.

Among other uses of testosterone, it is the highly important and necessary ingredient for the sperm development in males. This hormone helps in activating the genes in the cells for the differentiation of Spermatogonia. Testosterone provides the physical energy and it maintains the trophism for the muscles. If high androgen levels are found in females, then it makes the menstrual cycle irregular and abnormal and that can happen in the healthy women as well.

Testosterone plays an important role in the maintenance of cardiovascular health. If testosterone level in controlled in the elderly men, then it can decrease the total cholesterol level and decrease fat body mass. It is not known to cause any kind of deleterious effects on the cancer of prostrate. It can play a role in the fight responding time as well. Normally the men who have high level of testosterone are likely to have the high blood pressure and in that way their chances of getting heart attack decreases. However, they are more receptive towards injuries, infections transmitted sexually and other bad habits like smoking.

Along with many other uses, testosterone has its significance in medical use as well. Main use of testosterone is for the treatment of males who have the problem of endogenous testosterone production. This type of disease is known as hypogonadism. In this case, normally the treatment is done through the testosterone therapy in which the replacement is done and then the testosterone levels are maintained in the normal range. However, the replacement therapy may work well for some people, and in other cases, it may cause some problems. It can help in reducing the infertility, it can correct the erectile dysfunction and it can reverse the effects of anemia as well.

Testosterone is effective in giving treatment for the low libido level during the women post-menopausal. Sometimes, the strategies of testosterone are done to prevent loss of bone mass and to deal with any kind of depression. However, some women may face the side effects like increase in their weight and in that case their body fat is not increased but they may face some changes in muscle density. Another risk is that if a woman goes through testosterone therapy then they might face risk of getting breast or any other kind of gynecological cancers up to some extent.

There are many benefits and some adverse effects of testosterone therapy. It can really help in managing the diabetes of type 2. Sometimes, low testosterone level may increase the risk of diseases of high intensity, so therapy is necessary and advised in that case. However, it must important to note that some health risks are also involved with the testosterone therapy and prostate cancer may come apparent after few months of the testosterone therapy treatment.

Testosterone can also be very useful for athletes as well in order to improve their performance drastically. However, it is commonly considered as the doping case in many sports of players use the testosterone. Many other anabolic steroids including the testosterone can be used to strengthen the muscle development. If testosterone is used properly then it makes the fastening repair of the of the muscles fiber.

There are many methods that have been deployed for the detection of testosterone in the athletes and the most common one is the urine test. Among many administration routes for the testosterone the ones that are being used mostly commonly are injectables, buccals, transdermal creams, and some kinds of gels along with few others as well. It is believed that some other methods and nasal sprays will come soon for this purpose.

Wednesday, February 19, 2014

Trenbolone for Androgen Replacement Therapy


The use of the anabolic steroid trenbolone has a long history in the bodybuilding but it has never really been considered a steroid suitable for therapeutic use in medicine. The U.S. Food and Drug Administration has not approved tren for use in humans. The media has often demonized it as a dangerous veterinarian steroid never intended for human use.

Joshua Yarrow and his colleagues at the University of Florida feel that trenbolone may be a viable alternative to testosterone for androgen replacement therapy.  The researchers report that trenbolone enanthate may have certain advantages over testosterone that may make it an appealing treatment option for some individuals. Bodybuilders may be familiar with many of these findings.

Trenbolone is not adversely affected by the aromatase or 5-alpha reductase enzymes that metabolize testosterone into estradiol and dihydrotestosterone, respectively. Bodybuilders have enjoyed tren for years precisely because they are able to avoid steroid side effects related to estrogen and DHT.
Yarrow reports that low-dose trenbolone enanthate effectively produces anabolic effects in muscle size and partially maintains bone mineral density without causing prostate enlargement or polycythemia in castrated laboratory rats.

Supraphysiological dosages of testosterone enanthate were required to produce anabolic effects similar to low-dose trenbolone administration. However, negative side effects of prostate enlargement and elevated hemoglobin became problematic at this dose of testosterone.

Selective androgen receptor modulators (SARMs) may be the current darlings of scientific research into alternative options for androgen replacement therapy, but University of Florida researchers are excited by the “SARM-like potential” of trenbolone.

They suggest that the actions of trenbolone are similar to selective androgen receptor modulators (SARMs). Low-dose trenbolone is called “SARM-like” because of the positive anabolic effects in muscle and bone without negative side androgenic side effects of prostate enlargement or polycythemia.
Trenbolone may have benefits over testosterone in terms of androgen receptor activation, the upregulation of growth factors such as IGF-1 and fibroblast growth factor, and anticatabolic mechanisms.

Competitive bodybuilders have often preferred using trenbolone in the weeks prior to a bodybuilding competition due to its purported effects at accelerating fat loss.
The current study confirmed that trenbolone has more potent lipolytic effects on visceral adipose tissue than testosterone milligram per milligram. Furthermore, visceral fat loss increased in a dose-dependent manner with trenbolone. In other words, the more tren used, the greater the fat loss. Trenbolone’s lack of aromatization, while generally desirable, has often been problematic for bodybuilders who have used trenbolone as the only steroid in a cycle. Therefore, most bodybuilders include an aromatizable steroid such as testosterone or Dianabol in their trenbolone steroid stacks.

Researchers also recognize that the lack of aromatization could be a potential problem if trenbolone is used alone in androgen replacement therapy. In their study, trenbolone only provided a partial bone protective effect when administered to castrated rats. The authors attribute this to the non-aromatizable nature of trenbolone.

They conclude that low-dose trenbolone enanthate treatment has SARM-like effects on muscle/fat body composition. Androgen replacement therapy with low-dose trenbolone could potentially produce anabolic gains comparable to supraphysiological testosterone treatment without the associated side effects. The therapeutic risk-benefit profile of low-dose trenbolone appears superior to supraphysiological testosterone treatment; however, additional research into this treatment option is necessary.

The researchers should be applauded for dispassionately and objectively researching the potential of trenbolone in androgen replacement therapy. Trenbolone is an anabolic steroid that has been demonized more than others due to its limited use (in pellet implants used by veterinarians to increase muscle growth in livestock). Fortunately, they looked past the political stigma associated with trenbolone to revisit a therapeutic use for an old steroid.

Wednesday, February 12, 2014

HCG benefits for bodybuilding and fitness


If you are looking for an extremely potent weight loss drug that does not lead to loss of muscle definition, which is a common issue with other drugs for weight loss, Human chorionic gonadotropin or HCG is the best performance enhancing drug for you.

One of the biggest benefits associated with use of HCG is that it can easily trigger metabolism by burning fatty substances into calories to improve the process of digestion that helps in melting bulges and chubbiness of the body. In addition to this, the performance enhancing drug is also used to suppress appetite by stimulating the hypothalamus, which further controls cravings for junks and deeply fried foods to prevent obesity.

HCG has the chemical formula of C11H19N3O6S and its chemical name is (2S)-2-amino-6-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl] amino]-6-oxohexanoic acid. It includes 244 amino acids and has an active life of nearly 64 hours. Available in oral as well as injectable forms, human chorionic gonadotropin is also effective for improving circulation of blood in the body besides promoting immunity and stamina. When used for a period of three to six weeks, the drug can promote weight loss (around 20 to 40 lbs) besides treating men who are low on sperm count and young men with undescended testicles. Use of HCG in doses of 1500-3000 I.U. every fourth or fifth day is commonly associated with muscle mass, strength, stamina, performance, blood circulation, protein synthesis, and nitrogen retention improvements.

HCG should be used with great care as overdosing or abuse of it can lead to side effects like shortness of breath, erythema, urticaria, dyspnea, headache, and fatigue.

Thursday, February 6, 2014

Methyltestosterone and professional bodybuilding


Professional bodybuilding is a demanding sport and every one belonging to this world need to be on his toes and think, act before the rest so that success and invincibility remain unchallenged. This is where powerful anabolic steroids such as Methyltestosterone. Let us read about this potent steroid to find out how it can help professional bodybuilders.

Methyltestosterone is rated as second to none by sportsmen, especially those belonging to the fraternities of professional bodybuilding and strength athletics. This anabolic steroid provides minimal anabolic effects and is quite androgenic in its characteristics and benefits. Use of this steroid compound does not lead to steroid side effects, unless it is abused to a considerable extent or low-grade Methyltestosterone is used.

The steroid, Methyltestosterone, is highly effective for enhancing the level of aggression that is almost a requirement in today’s cutthroat sporting events. In the world of healthcare, this derivative of Testosterone is prescribed for treating males with deficiencies of androgen and needing replacement therapy and is also recommended for treating women with breast cancer.

The chemical name of Methyltestosterone is 17ß-hydroxy-17a-methylandrost-4-en-3-one and it has the molecular weight of 302.451 g/mol at the base. For the purpose of professional bodybuilding, this steroid can be used in doses of 150-200 mg per day while the recommended doses for cancer treatment and replacement therapy are 50-200 mg per week and 10-50 mg per day, respectively. The drug is not meant for use by pregnant or breastfeeding women and should not be abused else it can lead to side effects such as virilization, gynecomastia, and menstrual irregularities.